PixelShop

In spite of the fact that they are not so widespread anymore, the truth is that some of the games out there still employ 2D elements or sprites to create some animated objects or even characters. Depending on the tools you use to polish them, sometimes these sprites can look just as appealing as 3D elements.

Allows you to dock all tools you are using frequently

The setup is quick and forthright, whereas the app does not require any further configuration. Upon launch, there is a chance that you might get slightly confused or overwhelmed, especially since the program opens up all available features in separate docking stations.
The program comes with a clean, user-friendly interface and, as you probably already hinted, you can access its tools and functions via docking panels that you can move to any location on your desktop that you find convenient. Not only do you have complete freedom in moving the tools around, but you can also just keep only the ones that you are actually using.

Comes with layer system similar to advanced graphic editors

While at first you might get the impression that you are dealing with a simplistic app, you will be happy to learn that it packs several utensils to help you create complex sprite sheets, animations and icons for your latest applications. In fact, you should know that the utility includes a layer system that makes iterating of the drawings fast and smooth.
It is worth mentioning that the program includes a manual that details all the available functions as well as how you can use them for your project. In case you are having troubles finding a certain function or want to use it for a more complex project, do not hesitate to check out the documentation.

A small, but powerful sprite sheet designer

In the eventuality that you need an intuitive, yet powerful tool to create objects and characters for games or graphic applications you are working on, then perhaps PixelShop could lend you a hand.